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Metal Organic Frameworks (MOF’s)
MOFs are usually prepared under solvothermal or hydrothermal conditions in pure N, N-diethylformamide or N, N-dimethylformamide used as solvents, which slowly decompose upon heating in oven and generate bases of organic linker molecules which later on react with metal salts and produce 3D metal-organic networks.
Metal-Organic Frameworks are coordinated compounds consisting of metal ions correlated to often rigid organic molecules to form one, two or three-dimensional structures that can be porous.These metals are known to offer flexible, e.g. Tetrahedral, Trigonal bipyramidal square and pyramidal octahedral.In addition, due to the usual liability of metal complexes, the formation of coordination bonds between the metal ions and the organic linkers can be reversible. This property in fact enables the rearrangement of metal ions and organic linkers during the process of polymerization to render (provide) the highly ordered framework structures.
Metal-Organic Frameworks are coordinated compounds consisting of metal ions correlated to often rigid organic molecules to form one, two or three-dimensional structures that can be porous.These metals are known to offer flexible, e.g. Tetrahedral, Trigonal bipyramidal square and pyramidal octahedral.In addition, due to the usual liability of metal complexes, the formation of coordination bonds between the metal ions and the organic linkers can be reversible. This property in fact enables the rearrangement of metal ions and organic linkers during the process of polymerization to render (provide) the highly ordered framework structures.
Properties of Metal Organic Frameworks:
The unique properties of metal organic frameworks, like internal surface areas, Uniform channels, Low density, Nanometer (sub) sized cavities, thermal stability (above 300°C), adjustable chemical functionalities or chemical tailor ability, offer an ideal platform for the development of the sensitive layer. They can be considered as crystalline materials with tunable porosity (Pore volume: 1.59cm2/g), large internal surface area and organic functionality. The topology structure or surface area of MOFs can be controlled through choosing different organic linkers. They have structural diversity and specific adsorption affinity for the application in gas storage.
Applications
Metal organic frameworks have been widely used as drug delivery system for various applications because of their pore size and density. A range of novel structures has been prepared which feature amongst the largest pores known for crystalline compounds, very high absorption capacities and complex absorption behavior. Among the 10,000 of known MOFs, MIL family shows a unique candidate for storage and controlled release of biologically important molecules. In order for MOFs to be useful as efficient delivery vehicles for drugs and imaging contrast agents, the material composition must be biocompatible and the particle sizes must be carefully controlled to be uniform and below several hundred nanometers. The imaging and drug components can be directly incorporated into the MOFs either as metal-connecting points or as bridging ligands during the MOF synthesis.
- Medical Imaging
- Sensor:
- Biomedical Applications of MOFs:
